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V-ATPase Physiology and Pathophysiology Lab

Principal Investigator: Karlett J. Parra, PhD

Professor and Chair, Department of Biochemistry and Molecular Biology

Laboratory Photo

Karlett J. Parra

Contact the Laboratory

Lab Physical Address

Biomedical Research Facility, Room G25

Lab Mailing Address

Department of Biochemistry and Molecular Biology
MSC08 4670
1 University of New Mexico
Albuquerque, NM 87131-0001

Phone: (505) 272-1633
Fax: (505) 272-6587

Major Funding

Current Funding ($1 million or more): V-ATPase H+ Pump Regulation in Fuel Energy Selection (1R01GM086495, NIH/NIGMS; 2009-2015).

Recent Research

The V-ATPase Physiology and Pathophysiology Laboratory investigates the molecular mechanisms that regulate V-ATPase proton pumps and the downstream consequences of inhibiting V-ATPase proton transport in fungi (S. cerevisiae, C. albicans), cancer cell lines and primary cells. The emphasis is on the mechanisms by which V-ATPases sustain cellular pH homeostasis, interact with glucose metabolism and contribute to fungi pathogenesis and cancer.

Affiliated UNM Researchers

  • Samuel A. Lee, MD, PhD
  • Summer Hayek, PhD

Graduate Education

  • Yamhilette Licon-Munoz, MS, Graduate Student, BSGP Program
  • Dennis Dominguez, Graduate Student, BSGP Program