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BMB

Robert A. Orlando Laboratory

Principal Investigator: Robert A. Orlando, PhD

Associate Professor, Department of Biochemistry and Molecular Biology

Laboratory Photo

Robert A. Orlando

Contact the Laboratory

Lab Physical Address

Biomedical Research Facility, Room 224

Lab Mailing Address

Department of Biochemistry and Molecular Biology
MSC08 4670
1 University of New Mexico
Albuquerque, NM 87131-0001

Phone: (505) 272-5593
Fax: (505) 272-6587
E-mail: rorlando@salud.unm.edu

Research Interests

Orlando’s research is focused on obesity-dependent inflammation, lipid metabolism in obesity, and natural product drug discovery to identify novel therapeutic anti-inflammatory agents.

Recent Research

The laboratory has successfully identified a novel hepatic receptor that serves as the primary clearance receptor for atherogenic lipoproteins. It has also identified the associative properties of a tissue serine protease inhibitor with human breast cancer progression, suggesting a new tissue marker for breast cancer staging. It has identified and characterized a curcumin-based analog that prevents peptide aggregation leading to Alzheimer’s disease pathologies and characterized and quantified the anti-inflammatory properties of numerous natural products. It has identified a natural product with potent anti-inflammatory properties that is capable of preventing tissue pathologies of inflammatory bowel disease, and most recently, identified a novel cellular cross-talk communication event in obese adipose tissue that may be responsible for the chronic inflammatory status associated with obesity-dependent type II diabetes mellitus and atherogenic cardiovascular disease.