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Chien-An (Andy) Hu Laboratory

Principal Investigator: Chien-An (Andy) Hu, PhD

Associate Professor, Department of Biochemistry and Molecular Biology

Laboratory Photo

Chien-An "Andy" Hu

Contact the Laboratory

Lab Physical Address

Fitz Hall, Room 264

Lab Mailing Address

Department of Biochemistry and Molecular Biology
MSC08 4670
1 University of New Mexico
Albuquerque, NM 87131-0001

Phone: (505) 272-8816
Fax: (505) 272-6587
E-mail: ahu@salud.unm.edu

Research Interests

Hu was trained as a human geneticist and biochemist at Johns Hopkins Medical Institutes and has published peer-reviewed papers in ROS generation, apoptosis and autophagy, in human diseases, including cancer, atherosclerosis and end-stage kidney disease. In 2004, his laboratory pioneered the cloning and characterization of human apolipoprotein L6 (ApoL6), which, when overexpressed, induced mitochondria-mediated apoptosis in cancer cells. In addition, they also identified and characterized ApoL1, another member of the same family, which induces autophagy and Atg5 and Atg7-dependent cell death.

Recent Research

Hu’s team has recently demonstrated that ApoL6 is an important factor regulating mitochondria-mediated apoptosis, Beclin 1-dependent autophagy and inflammation. In this RO1 project, his group will use the unique cell models they recently developed to determine the mechanism by which si-APOL6 and nifedipine, a Ca++ channel antagonist, block apoptosis, enhance autophagic survival mechanism and regress inflammatory response.