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William S. Garver Laboratory

Principal Investigator: William S. "Sherm" Garver, PhD

Assistant Professor, Department of Biochemistry and Molecular Biology

Laboratory Photo

William S. "Sherm" Garver

Contact the Laboratory

Lab Physical Address

Fitz Hall, Room 265

Lab Mailing Address

Department of Biochemistry and Molecular Biology
MSC08 4670
1 University of New Mexico
Albuquerque, NM 87131-0001

Phone: (505) 272-4790
Fax: (505) 272-6587
E-mail: wgarver@salud.unm.edu

Research Interests

The Garver lab focuses on gene-diet and gene-gene interactions that predispose to common metabolic diseases such as obesity and diabetes. The focus is to determine the molecular basis for how Niemann-Pick C1 (NPC1) gene variants predispose to different yet coexistent metabolic diseases (obesity and diabetes).

Recent Research

The Garver lab and collaborators have a long history investigating the NPC1 gene/protein, which plays a central role in regulating cell, tissue and whole-body lipid metabolism. The group has performed the most basic of studies (mapping and cloning the NPC1 gene), investigating function of the NPC1 protein, identifying therapies to treat patients with NPC1 disease and directing the National NPC1 Disease Database.

Affiliated UNM Researchers

  • Mark Burge, MD
  • Vallabh O. Shah, PhD
  • Robert A. Orlando, PhD
  • Randall A. Heidenreich, MD

Outside Investigators and Collaborators

  • Renee C. LeBoeuf, PhD, Research Professor, University of Washington
  • David Meyre, PhD, Professor, McMaster University
  • Francis J. Meaney, Research Professor, University of Arizona